Biogenesis and function of macrocyclic spermine alkaloids
نویسندگان
چکیده
منابع مشابه
Isolation and identification macrocyclic spermine alkaloid(protoverbine) from verbascum speciosum.
The 17-membered macrocyclic spermine alkaloid protoverbine (8-phenyl-1,5,9,13-tetra azacycloheptadecan-6-one) was isolated From the aerial part of verbascum speciosum. The natural polyamines are ubiquitous bases reported to have several important functions in animals, plants and microorganisms. They are involved in processes of transcription and translation in protein synthesis and influence gr...
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ماکروسیکلهای شیف باز از اهمیت زیادی در شیمی آلی و دارویی برخوردار می باشند. این ماکروسیکلها با دارابودن گروه های مناسب در مکانهای مناسب می توانند فلزاتی مثل مس، نیکل و ... را در حفره های خود به دام انداخته، کمپلکسهای پایدار تولید نمایند. در این پایان نامه ابتدا یک دی آلدئید آروماتیک از گلیسیرین تهیه می شود و در مرحله بعدی واکنش با دی آمینهای آروماتیک و یا آلیفاتیک در رقتهای بسیار زیاد منجر به ت...
15 صفحه اولThe antiplasmodial activity of spermine alkaloids isolated from Albizia gummifera.
In the present study the methanolic extract of Albizia gummifera was fractionated into various fractions. These fractions were tested against choroquine sensitive (NF54) and resistant (ENT30) strains of Plasmodium falciparum. All other fractions apart from the alkaloidal fraction showed low activity with IC 50 above 3 microg/ml. The alkaloidal fraction exhibited strong activity against NF54 and...
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Three new spermidine alkaloids and two known compounds were isolated from the leaves of Androya decaryi. Their structures were elucidated on the basis of their spectroscopic data (NMR and mass spectrometry), by X-Ray diffraction and by comparison with literature values. Evaluation of the in vitro antiplamosdial properties of the isolated compounds revealed they did not possess any significant a...
متن کاملThe spider Paracoelotes birulai: detection and structure elucidation of new acylpolyamines by on-line coupled HPLC-APCI-MS and HPLC-APCI-MS/MS
The lyophilized venom of the spider Paracoelotes birulai (Araneidae: Amaurobiidae) has been analyzed. A no. of acylpolyamines were found and sepd. By online coupled high-performance liq. chromatog. and atm.-pressure chem.-ionization mass spectrometry, the structures of the three most abundant compds. PB 490 (N-(16-guanidino-4-hydroxy-4,8,12-triazahexadecyl)-2-(4-hydroxyindol-3-yl)acetamide), PB...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2001
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0002.817