Bioengineering of Physiologically Functional Intrinsically Innervated Human Internal Anal Sphincter Constructs
نویسندگان
چکیده
منابع مشابه
Successful implantation of physiologically functional bioengineered mouse internal anal sphincter.
We have previously developed bioengineered three-dimensional internal anal sphincter (IAS) rings from circular smooth muscle cells isolated from rabbit and human IAS. We provide proof of concept that bioengineered mouse IAS rings are neovascularized upon implantation into mice of the same strain and maintain concentric smooth muscle alignment, phenotype, and IAS functionality. Rings were bioeng...
متن کاملInternal anal sphincter: Clinical perspective.
OBJECTIVE To summarise current knowledge of Internal anal sphincter. BACKGROUND The internal anal sphincter (IAS) is the involuntary ring of smooth muscle in the anal canal and is the major contributor to the resting pressure in the anus. Structural injury or functional weakness of the muscle results in passive incontinence of faeces and flatus. With advent of new assessment and treatment mod...
متن کاملPhysio-pathology of the internal anal sphincter.
In normal physiological studies, using electrical, manometric, or cinematographic methods, it is practically impossible to separate the role of the internal sphincter from that of the other elements of the functional ensemble forming the anal sphincteric system (Aron and Thouvenot, 1962; Lawson and Nixon, 1967; Schnaufer et al., 1967). It is only by studying the pathology of the area that it is...
متن کاملInternal anal sphincter augmentation and substitution
There is an increasing recognition of the importance of internal anal sphincter (IAS) dysfunction presenting as passive faecal incontinence. This problem may manifest after anal sphincterotomy or following the more minimally invasive operations for haemorrhoids, as well as with advancing age. Because of the poor results of IAS plication and the beneficial outcomes with peri-urethral bulking age...
متن کاملInternal anal sphincter evaluation using 3D anal ultrasound.
A 42 year-old male, with no relevant medical history except surgery three years before for chronic anal fissure in another center (without information regarding type of surgery), attended outpatient clinic for several week-history of anal pain. The patient related a sudden anal pain without irradiation and without relationship with defecation that improved with flexion of the lower extremities....
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ژورنال
عنوان ژورنال: Tissue Engineering Part A
سال: 2014
ISSN: 1937-3341,1937-335X
DOI: 10.1089/ten.tea.2013.0422