Biochemistry of malaria parasite infected red blood cells by X-ray microscopy
نویسندگان
چکیده
منابع مشابه
Arresting malaria parasite egress from infected red blood cells.
The cyclical waves of fever and chills associated with malaria result from the synchronous rupture of infected red blood cells (RBCs) that release swarms of parasites into the bloodstream for subsequent reinvasion and proliferation. Despite the clinical importance of this phase of the malaria parasite life cycle, relatively little is known about the mechanisms used by the parasite to promote RB...
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Red blood cells (RBCs) parasitized by Plasmodium falciparum are rigid and poorly deformable and show abnormal circulatory behavior. During parasite development, knob-associated histidinerich protein (KAHRP) and P falciparum erythrocyte membrane protein 3 (PfEMP3) are exported from the parasite and interact with the RBC membrane skeleton. Using micropipette aspiration, the membrane shear elastic...
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Development of malaria parasites within vertebrate erythrocytes requires nutrient uptake at the host cell membrane. The plasmodial surface anion channel (PSAC) mediates this transport and is an antimalarial target, but its molecular basis is unknown. We report a parasite gene family responsible for PSAC activity. We used high-throughput screening for nutrient uptake inhibitors to identify a com...
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Background: Chest X-ray is one of the examinations required for an annual health checkup. The interaction of radiation to the medium produces free radicals, which consequently causes biological changes either structural or properties of the cells. Whether the radiation from Chest X-ray upright technique affects the plasma membrane fluidity of thalassemic red blood cells (RBCs) is still unclear....
متن کاملContribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells.
Red blood cells (RBCs) parasitized by Plasmodium falciparum are rigid and poorly deformable and show abnormal circulatory behavior. During parasite development, knob-associated histidine-rich protein (KAHRP) and P falciparum erythrocyte membrane protein 3 (PfEMP3) are exported from the parasite and interact with the RBC membrane skeleton. Using micropipette aspiration, the membrane shear elasti...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-00921-2