Biochemical nature of Russell Bodies
نویسندگان
چکیده
منابع مشابه
Biochemical nature of Russell Bodies.
Professional secretory cells produce and release abundant proteins. Particularly in case of mutations and/or insufficient chaperoning, these can aggregate and become toxic within or amongst cells. Immunoglobulins (Ig) are no exception. In the extracellular space, certain Ig-L chains form fibrils causing systemic amyloidosis. On the other hand, Ig variants lacking the first constant domain conde...
متن کاملThe Nature of Russell Bodies and Kurloff Bodies: Observations on the Cytochemistry of Plasma Cells and Reticulum Cells.
This paper describes the use of cytochemical methods to demonstrate the presence of a polysaccharide-containing substance which is either mucoprotein or glycoprotein in the cytoplasm of plasmacells and reticulum cells, in Russell bodies, and in the Kurloff bodies of guinea-pig lymphocytes. The work is based on the observation that the cytoplasm of a proportion of plasma cells stains pink by the...
متن کاملMott cell (Russell bodies) Barrett's oesophagitis.
The first case of Barrett's oesophagus with chronic inflammation having predominantly (> 50%) Mott cells, i.e. plasma cells with stored immunoglobulins, known as Russell bodies, is reported. Biopsies from two oesophagoscopies revealed similar changes, suggesting that the predominance of Mott cells is not a fortuitous event but a more long-lasting microscopic process. Periodic acid-Schiff (PAS) ...
متن کاملMultiple myeloma with numerous intranuclear Russell bodies.
Correspondence: A. Martín-Noya, M.D., Servicio de Hematología, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot s/n1, 41013 Seville, Spain. Phone: international +34-95-4248122 – Fax: international +34-954248124 – E-mail: [email protected] A71-year-old woman was admitted to hospital because of repeated episodes of epistaxis and an eight month history of fatigue and weight loss. On ph...
متن کاملCirculating plasma cells with Russell bodies in osteosclerotic myeloma.
A 58-year-old white female had severe bone pain for 1 week. Increased levels of free l light chain (2423 mg/L) were present in the serum with decreased levels of all immunoglobulins. The complete blood count and differential were within normal limits. The peripheral blood smear had increased rouleaux formation and atypical plasma cells containing numerous cytoplasmic Russell bodies (panel A). T...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep12585