Biochemical Increase in Phosphorylated Alpha-Synuclein Precedes Histopathology of Lewy-Type Synucleinopathies
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Calcium: Alpha-Synuclein Interactions in Alpha-Synucleinopathies
Aggregation of the pre-synaptic protein, α-synuclein (α-syn), is the key etiological factor in Parkinson's disease (PD) and other alpha-synucleinopathies, such as multiple system atrophy (MSA) and Dementia with Lewy bodies (DLB). Various triggers for pathological α-syn aggregation have been elucidated, including post-translational modifications, oxidative stress, and binding of metal ions, such...
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ژورنال
عنوان ژورنال: Brain Pathology
سال: 2012
ISSN: 1015-6305
DOI: 10.1111/j.1750-3639.2012.00585.x