Biochemical Characterization of Dichlorvos-Induced Delayed Neurotoxicity in Rat
نویسندگان
چکیده
منابع مشابه
3-nitrotyrosine levels in dichlorvos-induced neurotoxicity.
The aim of this study was to evaluate dichlorvos toxicity in terms of nitro-oxidative stress by determining 3-nitrotyrosine (3-NT) levels in the fore, mid, and hindbrain regions in acutely exposed rats. Male Sprague- Dawley rats were randomly allocated to three groups of eight. Group 1 was administered a single intraperitoneal dichlorvos dose of 1.8 mg kg ⁻¹(0.1xLD₅₀) and group 2 a dose of 9 mg...
متن کاملEster-induced Delayed Neurotoxicity
Most organophosphorus esters are direct inhibitors or are rapidly converted to inhibitors of acetylcholinesterase (AChE, EC 3.1.1.7) (1-3). Some of these compounds produce a more persistent effect: delayed neurotoxicity. In humans, organophosphorus ester-induced delayed neurotoxicity (OPIDN) results in a flaccid paresis which develops distally in the legs and spreads to the hands and thighs. In...
متن کاملTherapeutic effects of nano-HAp in a rat model of AlCl3 induced neurotoxicity
With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) into male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/...
متن کاملTherapeutic effects of nano-HAp in a rat model of AlCl3 induced neurotoxicity
With the advance in nanomedicine, the present study was conducted to explore the possible therapeutic role of intravenous nano- hydroxyapatite (nano-HAp) into male rats after chronic exposure to aluminum chloride (AlCl3). This exposure interposed DNA fragmentation, apoptosis, alters oxidant/antioxidant status as well as change in content of neurotransmitters. The rats were injected with 100 mg/...
متن کاملProtective Role of Oleuropein against Acute Deltamethrin- Induced Neurotoxicity in Rat Brain
Background: Deltamethrin (DM) is a synthetic pyrethroid insecticide that can elicit neurotoxicity, leading to apoptosis. There is accumulating evidence that oleuropein (OE) has anti-apoptotic effect. The purpose of this study was to determine the anti-apoptotic effect of OE pretreatment in the neuronal cells of cerebral cortex. Methods: Rats were randomly divided into four groups each containin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IUBMB Life (International Union of Biochemistry and Molecular Biology: Life)
سال: 2000
ISSN: 1521-6543,1521-6551
DOI: 10.1080/15216540050022449