Biochemical Basis of Sestrin Physiological Activities

Physiological and biochemical basis of salmon young fishes migratory behavior

Initial stages of salmonid fishes development are carried out in freshwater. At the first stage young fishes form structures and systems connected with ability to live in freshwater. At the second stage a complex of structural, physiological and biochemical changes directed on preparation of the organism for downstream migration and seawater entry takes place[1]. After completion of smoltificat...

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

Sestrins are highly conserved, stress-inducible proteins that inhibit target of rapamycin complex 1 (TORC1) signaling. After their transcriptional induction, both vertebrate and invertebrate Sestrins turn on the adenosine monophosphate (AMP)-activated protein kinase (AMPK), which activates the tuberous sclerosis complex (TSC), a key inhibitor of TORC1 activation. However, Sestrin overexpression...

Physiological Basis of Exercise

Biochemical oxygen activation as the basis for the physiological action of tetrachlorodecaoxide (TCDO).

Oxidation of methionine, 4-(methylthio)-2-oxobutyric acid (KMB), or 1-aminocyclopropane carbonic acid (ACC) are indicator reactions for activated oxygen species such as singlet oxygen (1O2), OH.-radical like oxidants, superoxide anion (O2.-), hydrogen peroxide (H2O2) or activated hemo-iron complexes like peroxidase- or catalase-"compound I". Methionine is oxidized by OH. as well as by 1O2 formi...

The Biochemical Basis of Neuropharmacology

portant in the fetal and neonatal periods, and finally, EP studies in human disease. The monograph tells us that EP is the principle hormone which regulates erythropoiesis. It is a glycoprotein with a molecular weight of 60,000 to 70,000. The kidney produces either the hormone itself or an enzyme activating the plasma substrate. The site of EP production in the kidney is unknown, but the greate...