Biochemical Aspects of Coronavirus Replication and Virus-Host Interaction
نویسندگان
چکیده
منابع مشابه
Biochemical aspects of coronavirus replication.
infected cells. Nevertheless, there is a limited knowledge of the biochemical events occurring in host cells and in the biochemistry of the infection. Infections by CoVs cause alterations in host cells in transcription and translation patterns, in the cell cycle, in the cytoskeleton, and in apoptosis pathways. In addition, in the host, CoV infection may cause inflammation, alterations of the im...
متن کاملEvidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
The recent outbreak of coronavirus infectious disease 2019 (COVID- 19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. Scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARSCoV) at the genomic and transcriptomic level. Simila...
متن کاملCoronavirus Gene 7 Counteracts Host Defenses and Modulates Virus Virulence
Transmissible gastroenteritis virus (TGEV) genome contains three accessory genes: 3a, 3b and 7. Gene 7 is only present in members of coronavirus genus a1, and encodes a hydrophobic protein of 78 aa. To study gene 7 function, a recombinant TGEV virus lacking gene 7 was engineered (rTGEV-Δ7). Both the mutant and the parental (rTGEV-wt) viruses showed the same growth and viral RNA accumulation kin...
متن کاملHuman T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL)
The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only ...
متن کاملThe interaction between NOLC1 and IAV NS1 protein promotes host cell apoptosis and reduces virus replication
NS1 of the influenza virus plays an important role in the infection ability of the influenza virus. Our previous research found that NS1 protein interacts with the NOLC1 protein of host cells, however, the function of the interaction is unknown. In the present study, the role of the interaction between the two proteins in infection was further studied. Several analyses, including the use of a p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annual Review of Microbiology
سال: 2006
ISSN: 0066-4227,1545-3251
DOI: 10.1146/annurev.micro.60.080805.142157