Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata

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Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata

BACKGROUND Veronica ciliata Fisch., widely distributed in western China, has been traditionally used in Tibetan Medicine as a treatment for hepatitis, cholecystitis, rheumatism, and urticaria. However, V. ciliata Fisch. has not been subjected to detailed chemical constitution analysis and the bioactive studies were restricted to its crude extracts. It is necessary to investigate the active chem...

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HSCCC Separation of the Two Iridoid Glycosides and Three Phenolic Compounds from Veronica ciliata and Their in Vitro Antioxidant and Anti-Hepatocarcinoma Activities.

Five main compounds, including two iridoid glycosides (catalposide, verproside) and three phenolic compounds (luteolin, 4-hydroxy benzoic acid, 3,4-dihydroxy benzoic acid), were separated and prepared from the crude extract of Veronica ciliata by high-speed countercurrent chromatography. n-Hexane/n-butanol/water (1.5:5:5, v/v/v) was used for the separation of catalposide and verproside. n-Hexan...

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ژورنال

عنوان ژورنال: Chemistry Central Journal

سال: 2016

ISSN: 1752-153X

DOI: 10.1186/s13065-016-0172-1