Bioactivation and Cytotoxicity of 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123) in Isolated Rat Hepatocytes*

Four-Week Inhalation Toxicity Study of 2,2-Dichloro-1,1,1- trifluoroethane (HCFC-123) in Guinea Pigs

Four-Week Inhalation Toxicity Study of 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) in Guinea Pigs: Isamu KABE, et al. Department of Preventive Medicine and Public Health, School of Medicine, Keio University—Groups of eight male Hartley guinea pigs were exposed to 30, 100 or 300 ppm 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) by inhalation for 6 hours a day for 4 wk. All the animals were sac...

molecular mechanisms of methimazole cytotoxicity in isolated rat hepatocytes

Metabolism and cytotoxicity of hydrazine in isolated rat hepatocytes.

Metabolism and Cytotoxic Mechanisms of Nitroglycerin in Isolated Rat Hepatocytes

     It has been proposed that organic nitrates such as glyceryl trinitrate (GTN), used in the treatment of cardiovascular diseases, act by producing nitric oxide (NO). However, the biochemical pathway for NO formation from GTN is not well understood. In the present study, we showed that nitrate formation from GTN, by isolated rat hepatocytes, was inhibited about 50% when cellular glutathione w...

Chloroacetonitrile-Induced Cytotoxicity and Oxidative Stress in Isolated Rat Hepatocytes

Chloroacetonitrile (CAN) is a disinfectant by-product of drinking water chlorination. The present work was designed to investigate the cytotoxic effects as well as the oxidative stress induced by CAN in isolated rat hepatocytes. Hepatocytes were exposed to different concentrations of CAN (5–40 μM) in a time-course experiment for up to 2 h. CAN exposure induced a significant decrease in cell via...