Binge alcohol alters PNPLA3 levels in liver through epigenetic mechanism involving histone H3 acetylation
نویسندگان
چکیده
منابع مشابه
Acetylation of histone H3 at the nucleosome dyad alters DNA-histone binding.
Histone post-translational modifications are essential for regulating and facilitating biological processes such as RNA transcription and DNA repair. Fifteen modifications are located in the DNA-histone dyad interface and include the acetylation of H3-K115 (H3-K115Ac) and H3-K122 (H3-K122Ac), but the functional consequences of these modifications are unknown. We have prepared semisynthetic hist...
متن کاملGene-selective histone H3 acetylation in the absence of increase in global histone acetylation in liver of rats chronically fed alcohol.
AIMS The aim of this study was to determine the effect of chronic ethanol feeding on acetylation of histone H3 at lysine 9 (H3-Lys9) at promoter and coding regions of genes for class I alcohol dehydrogenase (ADH I), inducible nitric oxide synthase (iNOS), Bax, p21, c-met and hepatocyte growth factor in the rat liver. METHODS Rats were fed ethanol-containing liquid diet (5%, w/v) for 1-4 weeks...
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The elongating, hyperphosphorylated form of RNA polymerase II is associated with the Elongator complex, which has the histone acetyltransferase (HAT) Elp3 as a subunit. Here we show that, in contrast to the isolated Elp3 subunit, the activity of intact Elongator complex is directed specifically toward the amino-terminal tails of histone H3 and H4, and that Elongator can acetylate both core hist...
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The MRM transitions used to detect histone H3K56 peptides were as follows.
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Histone H3 phosphorylation is a critical step that couples signal transduction pathways to gene regulation. To specifically assess the transcriptional regulatory functions of H3 phosphorylation, we developed an in vivo targeting approach and found that the H3 kinase MSK1 is a direct and potent transcriptional activator. Targeting of this H3 kinase to the endogenous c-fos promoter is sufficient ...
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ژورنال
عنوان ژورنال: Alcohol
سال: 2017
ISSN: 0741-8329
DOI: 10.1016/j.alcohol.2017.01.009