منابع مشابه
Nuclear triiodothyronine-binding protein: partial characterization and binding to chromatin.
Nuclei were prepared by sucrose sedimentation of liver homogenates from rats given (125)I-labeled triiodothyronine in vivo. The nuclear extract obtained by treatment of the nuclear pellet with 0.4 M KCl contains the [(125)I]triiodothyronine that had been injected in vivo bound to protein(s). The triiodothyronine bound to nuclear protein(s) in vivo does not readily exchange with triiodothyronine...
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Thrombocytopenia is a critical problem that occurs in many hematologic diseases, as well as after cancer therapy and radiation exposure. Platelet transfusion is the most commonly used therapy but has limitations of alloimmunization, availability, and expense. Thus, the development of safe, small, molecules to enhance platelet production would be advantageous for the treatment of thrombocytopeni...
متن کاملManganese and Iron Binding to Human Transferrin
The characteristics of manganese and iron binding to human apotransferrin (apo-tf) have been investigated and compared in this study. Both metal ions were taken up by human apo-tf and formed complexes, with the maximum absorbances observed at 410 and 340 nm for manganese-transferrin (Mn-tf) and 465 nm for iron-transferrin (Fe-tf). Addition of manganese (1.5 µg/ml) to the reaction mixture contai...
متن کاملBinding of Chemical Carcinogens to Nuclear Proteins of Rat Liver1
liver nuclei was studied. After the injection of the radioactive carcinogens into rats, liver histone fractions Fl, F2al, F2a2, F2b, and F3 were isolated by selective acid extraction. DNA and acidic proteins were extracted with 4 M CsCl at pH 11.6 and 14 and were separated by equilibrium density centrifugation. Histones and acidic proteins were purified by Sephadex chiomatography. Maximum level...
متن کاملBinding of chemical carcinogens to nuclear proteins of rat liver.
liver nuclei was studied. After the injection of the radioactive carcinogens into rats, liver histone fractions Fl, F2al, F2a2, F2b, and F3 were isolated by selective acid extraction. DNA and acidic proteins were extracted with 4 M CsCl at pH 11.6 and 14 and were separated by equilibrium density centrifugation. Histones and acidic proteins were purified by Sephadex chiomatography. Maximum level...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1987
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)58344-5