BIMG-12. [18F]FLUCICLOVINE PET TO DISTINGUISH PSEUDOPROGRESSION FROM TUMOR PROGRESSION IN POST-TREATMENT GLIOBLASTOMA

Progression or Pseudoprogression? A Review of Post- Treatment MRI Appearances of Glioblastoma

Tumour progression or pseudoprogression? A review of post-treatment radiological appearances of glioblastoma.

Glioblastoma (GBM) is a common brain tumour in adults, which, despite multimodality treatment, has a poor median survival. Efficacy of therapy is assessed by clinical examination and magnetic resonance imaging (MRI) features. There is now a recognised subset of treated patients with imaging features that indicate "progressive disease" according to Macdonald's criteria, but subsequently, show st...

Differentiation of tumor progression from pseudoprogression in patients with posttreatment glioblastoma using multiparametric histogram analysis.

BACKGROUND AND PURPOSE The multiparametric imaging can show us different aspects of tumor behavior and may help differentiation of tumor recurrence from treatment related change. Our aim was to differentiate tumor progression from pseudoprogression in patients with glioblastoma by using multiparametric histogram analysis of 2 consecutive MR imaging studies with relative cerebral blood volume an...

Parametric response map as an imaging biomarker to distinguish progression from pseudoprogression in high-grade glioma.

PURPOSE To assess whether a new method of quantifying therapy-associated hemodynamic alterations may help to distinguish pseudoprogression from true progression in patients with high-grade glioma. PATIENTS AND METHODS Patients with high-grade glioma received concurrent chemoradiotherapy. Relative cerebral blood volume (rCBV) and blood flow (rCBF) maps were acquired before chemoradiotherapy an...

Pseudoprogression in glioblastoma.

TO THE EDITOR: Brandes et al are to be congratulated for their article describing a phenomenon of apparent tumor progression in newly diagnosed patients with glioblastoma (GBM) treated with concurrent temozolomide (TMZ) and radiotherapy (RT). Of 208 patients treated with the regimen, 103 were analyzed for O-methylguanineDNA methyltransferase (MGMT) tumor content, radiographic course during ther...