Bilirubin Conjugation and Biliary Bilirubin Excretion after Intravenous Bilirubin Injection in Dogs.
نویسندگان
چکیده
منابع مشابه
Bile pigment excretion: a comparison of the biliary excretion of bilirubin and bilirubin derivatives.
During the process of hepatic excretion, a diverse group of exogenous organic compounds and endogenous metabolites is conjugated with polar anionic molecules (1). Although it is clear that the physical and chemical characteristics of these compounds can be drastically altered by conjugation, the relationship between conjugation and excretion has not been fully elucidated (2). Formation of the g...
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The effect of phenobarbital on bilirubin excretion was studied in rats with different capacities for bilirubin conjugation. Drug treatment induced substantial increases in bilirubin UDP-glucuronyl transferase activity in the liver of both normal and heterozygous Gunn rats, but not homozygous Gunn rats in which enzyme activity is completely absent. However, enhancement of bilirubin excretion in ...
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Adlard, B. P. F., and Lathe, G. H. (1970). Archives of Disease in Childhood, 45, 186. Breast milk jaundice: effect of 3oc,20,B-pregnanediol on bilirubin conjugation by human liver. The effect of 3ot,20fl-pregnanediol and other steroids on bilirubin conjugation was examined using liver tissue from human and four other species. Neither 3Ix,20fl-pregnanediol nor 3a,200c-pregnanediol inhibited conj...
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Dogs and humans excrete only conjugated bilirubin in the urine, principally the diglucuronide, and unconjugated bilirubin is not excreted by the kidneys (1). Previous studies concerning the renal excretion of bilirubin have not resolved the issue of whether it is filtered through the glomeruli or is secreted by the tubules (2, 3). Bilirubin in the plasma has been reported to be completely bound...
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Hargreaves, T. (1973). Archives of Disease in Childhood, 48, 446. Effect of fatty acids on bilirubin conjugation. The effect of fatty acids on bilirubin conjugation has been studied. Unsaturated fatty acids containing 18 to 20 carbon atoms decreased the rate of conjugation in rat liver slices and microsomes, probably by inhibiting glucuronyl transferase. Since fatty acids may be an important so...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1991
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.165.67