Bile acid transporters

Electrogenicity of Na(+)-coupled bile acid transporters.

The Na(+)-bile acid cotransporters NTCP and ASBT are largely responsible for the Na(+)-dependent bile acid uptake in hepatocytes and intestinal epithelial cells, respectively. This review discusses the experimental methods available for demonstrating electrogenicity and examines the accumulating evidence that coupled transport by each of these bile acid transporters is electrogenic. The evidenc...

Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Transporters influence the disposition of chemicals within the body by participating in absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) comprise a variety of proteins, including organic cation transporters (OCT) 1 to 3, organic cation/carnitine transporters (OCTN) 1 to 3, organic anion transporters (OAT) 1 to 7, various organic anion transporting polyp...

Role of hepatic transporters in prevention of bile-acid toxicity

Role of hepatic transporters in prevention of bile-acid toxicity 1 after partial hepatectomy in mice 2 3 4 5 6 7 8 Iván L. Csanaky, Lauren M. Aleksunes, Yuji Tanaka, and Curtis D. Klaassen 9 10 11 12 13 14 15 16 Department of Pharmacology, Toxicology, and Therapeutics 17 University of Kansas Medical Center 18 3901 Rainbow Blvd. 19 Kansas City, Kansas 20 21 22 23 Running head: Bile acids and hep...

Enterohepatic bile acid transporters and transcriptional control of their expression

Molecular regulation of sinusoidal liver bile acid transporters during cholestasis.

Impairment of the hepatic transport of bile acids and other organic anions will result in the clinically important syndrome of cholestasis. Cloning of a number of specific hepatic organic anion transporters has enabled studies of their molecular regulation during cholestasis. The best characterized transport system is a 50-51 kDa sodium-dependent taurocholate cotransporting polypeptide (ntcp), ...