<b><i>Inflammatory Intestinal Diseases</i></b> - The Second Issue: ‘Mucosal Inflammation'
نویسندگان
چکیده
منابع مشابه
Mucosal Macrophages in Intestinal Homeostasis and Inflammation
Intestinal macrophages are essential for local homeostasis and in keeping a balance between commensal microbiota and the host. However, they also play essential roles in inflammation and protective immunity, when they change from peaceful regulators to powerful aggressors. As a result, activated macrophages are important targets for treatment of inflammatory bowel diseases such as Crohn's disea...
متن کاملAnnexin A1 regulates intestinal mucosal injury, inflammation, and repair.
During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation and severity of injury. Secretion of anti-inflammatory mediators is a mechanism that is critical in controlling inflammatory responses and promoting epithelial restitution and barrier recovery. AnxA1 is a potent anti-inflammatory protein that has been implicated to play a critical im...
متن کاملThrombospondin 1 Modulates Monocyte Properties to Suppress Intestinal Mucosal Inflammation.
Monocytes (Mos) play an important role in the pathogenesis of intestinal mucosal inflammation. This study aims to investigate the mechanism by which the intestinal epithelial cell-derived thrombospondin 1 (TSP1) modulates Mo properties and regulates intestinal inflammatory responses. In this study, the production of TSP1 by intestinal epithelial cells was evaluated by quantitative real-time PCR...
متن کاملIntestinal mucosal inflammation leads to systemic genotoxicity in mice.
Inflammatory bowel disease, including ulcerative colitis and Crohn's disease, substantially increases the risk of colorectal cancer. However, mechanisms linking mucosal inflammation to the sequence of dysplasia are incompletely understood. Whereas studies have shown oxidative damage to the colon, this study tests whether genotoxicity is elicited systemically by acute and chronic intestinal infl...
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ژورنال
عنوان ژورنال: Inflammatory Intestinal Diseases
سال: 2016
ISSN: 2296-9403,2296-9365
DOI: 10.1159/000446624