Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes

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Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.

Imprinting of the maternally-expressed Igf2r gene is controlled by an intronic imprint control element (ICE) known as Region2 that contains the promoter of the noncoding Air RNA, whose transcript overlaps the silenced paternal Igf2r promoter in an antisense orientation. Two novel imprinted genes, Slc22a2 and Slc22a3 are described here that lie 110 and 155 kb 3' to Igf2r and that are not overlap...

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ژورنال

عنوان ژورنال: Genes & Development

سال: 2001

ISSN: 0890-9369

DOI: 10.1101/gad.206201