منابع مشابه
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Many methods for the detection of genomic DNA methylation states have appeared. Currently, nearly all such methods employ bisulfite-mediated deamination of denatured DNA. While this treatment effectively deaminates cytosines to uracils, leaving most 5-methylcytosines intact, it also introduces abasic sites that generate a significant number of single-strand breaks in DNA. We have investigated t...
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ژورنال
عنوان ژورنال: Academic Medicine
سال: 2019
ISSN: 1040-2446
DOI: 10.1097/acm.0000000000002879