Beta-cell neogenesis in type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Beta-Cell Function and Failure in Type 2 Diabetes
The main role of beta-cell is to synthesize and secrete insulin in order to maintain circulating glucose levels within physiological range. Although there exist several triggers of insulin secretion like nutrients (amino acids such as leucine, glutamine in combination with leucine, nonesterified fatty acid), hormones, neurotransmitters and drugs (sulfonylurea, glinides), glucose represents the ...
متن کاملBeta-cell function and mass in type 2 diabetes.
The aim of the work described here was to improve our understanding of beta-cell function (BCF) and beta-cell mass (BCM) and their relationship in vivo using the minipig as a model for some of the aspects of human type 2 diabetes (T2DM). More specifically, the aim was to evaluate the following questions: How is BCF, especially high frequency pulsatile insulin secretion, affected by a primary re...
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The incidence of and susceptibility to Type 2 diabetes increases with age, but the underlying mechanism(s) within beta cells that contribute to this increased susceptibility have not been fully elucidated. Here we review how aging affects the proliferative and regenerative capacity of beta cells and how this impacts beta cell mass. In addition we review changes that occur in beta cell function ...
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1. Department of Medicine IV, Tübingen University Hospital, Tübingen, Germany 2. Royal Liverpool University Hospital, Liverpool, UK; AstraZeneca, Luton, UK 3. Department of Endocrinology, University Hospital of Leuven, Leuven, Belgium 4. Division of Diabetology, St. Josef-Hospital, Ruhr-University, Bochum, Germany 5. Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denma...
متن کاملPharmacogenomic approach in type 2 diabetes treatment
Introduction: Type 2 diabetes (T2D) is chronic health caused by the interaction between genetic and environmental factors that results in high blood glucose. The evidence-based guidelines for diabetes management are mainly based on lifestyle changes, control of risk factors, and the management of blood glucose levels. Although numerous antidiabetic agents have been developed over time, T2D trea...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2001
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diabetes.50.2007.s186