Beta-adrenoceptor partial agonists: a renaissance in cardiovascular therapy?
نویسندگان
چکیده
منابع مشابه
Viewpoint: untoward effects of beta-adrenoceptor agonists in asthma.
Beta-adrenoceptor agonists are potent and selective relaxants of airway smooth muscle. They produce symptomatic bronchodilatory effects and are the most widely used therapy in asthma. In patients with asthma, they usually effect a reduction of airway resistance, but there have been several reports of episodes of increased airway obstruction, arterial hypoxaemia and even death associated with su...
متن کاملInhibition of ultrasonic vocalizations by beta-adrenoceptor agonists.
Infant rat ultrasonic vocalizations (USVs) are widely believed to result from the induction of an emotional state of anxiety or distress. This perspective, however, is not easily reconciled with the demonstration by W. J. Farrell and J. R. Alberts 2000 that norepinephrine, a nonselective beta-adrenoceptor agonist with anxiogenic properties, inhibits production of USVs. Here, Farrell and Alberts...
متن کاملWhy are long-acting beta-adrenoceptor agonists long-acting?
The extended duration of bronchodilation due to formoterol and salmeterol greatly exceeds that of short acting beta 2-adrenoceptor agonists, such as salbutamol or terbutaline. This extended duration and their capacity to "reassert" airway smooth muscle relaxation in vitro despite repeated washing has prompted considerable debate on the underlying mechanism(s). The comparative pharmacology, and ...
متن کاملSome pharmacodynamic aspects on long-acting beta-adrenoceptor agonists.
1. Formoterol and salmeterol are the first members of a new generation of long-acting beta(2)-adrenoceptor agonists for inhalation. The discovery of the long effect duration of formoterol was made by chance, while the development of salmeterol appeared to follow a purposeful research strategy. 2. Preclinical evaluation predictive of the clinical duration of effect of long-acting bronchodilators...
متن کاملInteractions of some partial agonists with beta-adrenoceptor in the isolated taenia caecum and tracheal smooth muscle of guinea pig.
The indexes for agonistic activity (pD2 values) and for antagonistic activity (pA2 values) of some beta-adrenergic partial agonists were estimated in the isolated taenia caecum and tracheal preparation of guinea pig. The pK1 values, negative log of dissociation constants, were also estimated by photoinactivation of the beta-adreneoceptor in the taenia caecum. The pD2 values of the partial agoni...
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 1990
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.1990.tb03760.x