Best antibiotic

Making the Best First Choice Antibiotic Selections

Antibiotic Cycling and Antibiotic Mixing: Which One Best Mitigates Antibiotic Resistance?

Can we exploit our burgeoning understanding of molecular evolution to slow the progress of drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to resistance during antibiotic treatment and to hinder that evolutionary course. But can this be done at a hospital-wide scale? Clinicians and theoreticians tried to when they proposed two conflicting behavioral ...

Comment on: Best in class: a good principle for antibiotic usage to limit resistance development?

Sir, We wish to comment on the article by Amyes et al., in which we are referenced as stating that ‘the concept that ertapenem is unlikely to increase resistance in non-fermenters is flawed’. We in fact did not state this and, on the contrary, we agree with the conclusions of Livermore et al. that selection (of carbapenemresistant Pseudomonas aeruginosa in particular) is unlikely under physiolo...

Evaluation of the best method to assess antibiotic potentiation by phytochemicals against Staphylococcus aureus.

The increasing occurrence of bacterial resistance to antibiotics has now reached a critical level. Finding antibiotic coadjuvants capable to inhibit the bacterial resistance mechanisms would be a valuable mid-term solution, until new classes of antibiotics are discovered. Selected plant alkaloids were combined with 5 antibiotics against 10 Staphylococcus aureus strains, including strains expres...

Best in class: a good principle for antibiotic usage to limit resistance development?

The causes of antibiotic resistance are often complex and it is difficult to identify strategies to prevent or delay its emergence. One strategy has been to use less active members of a drug class, so that when resistance develops the more active members will still prevail. This strategy may often fail because this resistance may form the basis of resistance to the whole class. Often, less acti...