Berberine Induces p53-Dependent Apoptosis through Inhibition of DNA Methyltransferase3b in Hep3B Cells
نویسندگان
چکیده
منابع مشابه
Berberine inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells.
Berberine has anti-tumor properties in some cancer cells including prostate cancer, but the exact mechanisms and in vivo effects are unclear. We investigated anti-cancer activity of berberine in vitro and in vivo, and possible mechanisms in prostate cancer cells. Berberine treatment inhibited cell cancer growth in a concentration (0-50 microM) and time- (0-48 h) dependent manner without any gro...
متن کاملCurcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway
OBJECTIVE Curcumin (diferuloylmethane) is a yellow-colored polyphenol with antiproliferative and proapoptotic activities to various types of cancer cells. This study explored the mechanism by which curcumin induces p53-null hepatoma cell apoptosis. RESULTS AKT, FOXO1, and FOXO3 proteins were downregulated after curcumin treatment. Conversely, PTEN was upregulated. Subcellular fractionations r...
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Cadmium (Cd), a harmful metal, exerts severe toxic effects on various tissues such as those in the kidney, liver, lung, and bone. In particular, renal toxicity with damage to proximal tubule cells is caused by chronic exposure to Cd. However, the molecular mechanism underlying chronic Cd renal toxicity remains to be understood. In this review, we present our recent findings since we examined to...
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Mohammad A Khasawneh1*, Adrian Koch4, Hanan M Elwy2, Alaaeldin A Hamza2,3 and Regine Schneider-Stock4 1Department of Chemistry, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE 2National Organizations of Drug Control and Research, 6 Abu Hazem St., Giza, Egypt 3Department of Biology, Faculty of Science U.A.E. University, Al-Ain, P.O. Box 17551, UAE 4Experimental Tumorpathology, ...
متن کاملCadmium Induces p53-Dependent Apoptosis in Human Prostate Epithelial Cells
Cadmium, a widespread toxic pollutant of occupational and environmental concern, is a known human carcinogen. The prostate is a potential target for cadmium carcinogenesis, although the underlying mechanisms are still unclear. Furthermore, cadmium may induce cell death by apoptosis in various cell types, and it has been hypothesized that a key factor in cadmium-induced malignant transformation ...
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ژورنال
عنوان ژورنال: The Korean Journal of Clinical Laboratory Science
سال: 2020
ISSN: 1738-3544,2288-1662
DOI: 10.15324/kjcls.2020.52.1.69