Berberine ameliorates non‑alcoholic steatohepatitis in ApoE-/- mice
نویسندگان
چکیده
منابع مشابه
Berberine ameliorates non-alcoholic steatohepatitis in ApoE−/− mice
The aim of the present study was to explore the protective effects of Berberine (BBR) against non-alcoholic steatohepatitis (NASH). Male 4-week-old C57BL/6J Apolipoprotein E-deficient (ApoE-/-) mice were divided into the following three groups, which were given different diets: Normal chow diet (SC group); high-fat high-cholesterol diet (HFHC group); and HFHC diet supplemented with BBR (BBR gro...
متن کاملBerberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats
Berberine is a plant alkaloid that has several pharmacological effects such as antioxidant, antilipidemic, and anti-inflammatory effects. Nonalcoholic steatohepatitis (NASH) triggers different aspects of disorders such as impaired endogenous lipid metabolism, hypercholesterolemia, oxidative stress, and neurotoxicity. In this study, we examined the mechanism by which NASH induces neurotoxicity a...
متن کاملQuercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis.
We investigated whether quercetin protects from steatosis and limits the expression of proinflammatory and fibrogenic genes in C57BL/6J mice with nonalcoholic steatohepatitis (NASH) induced by feeding a methionine-choline-deficient (MCD) diet. Quercetin (50 mg/kg) was given by oral route daily. Mice were randomly divided into 4 groups that received for 2 or 4 wk: the control diet plus vehicle, ...
متن کاملNonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a common liver disorder that represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, type II diabetes, hypertension and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury that carries a ris...
متن کاملNecroptosis in Nonalcoholic Steatohepatitis
Figure 1. Necroptosis is activated in human nonalcoholic steatohepatitis (NASH) samples. Representative immunohistochemical staining for phospho-MLKL on livers from different controls (Ctl) and NASH patients. Note the specific granular cytoplasmatic staining. See Gautheron et al for the specifics of the NASH cohort as well as the technical and ethical aspects. Dear Editor: One fundamental step ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Therapeutic Medicine
سال: 2017
ISSN: 1792-0981,1792-1015
DOI: 10.3892/etm.2017.5051