Benzamil-mediated urine alkalization is caused by the inhibition of H<sup>+</sup>-K<sup>+</sup>-ATPases
نویسندگان
چکیده
Bolus application of epithelial Na + channel (EnaC) blockers causes marked and acute increases urine pH. Here, we provide evidence that the underlying mechanism involves direct inhibition H -K pump in collecting duct. This could a fundamental revision previously assumed suggested key role ENaC this response.
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ژورنال
عنوان ژورنال: American Journal of Physiology-renal Physiology
سال: 2021
ISSN: ['1522-1466', '1931-857X']
DOI: https://doi.org/10.1152/ajprenal.00444.2020