Benefits of Sebastiania hispida (Euphorbiaceae) extract and photobiomodulation therapy as potentially adjunctive strategies to be explored against snake envenoming

The purpose of this study was to assess the topic use Sebastiania hispida extract and low-level gallium-arsenide laser irradiation (GaAs, 904 nm) reduce local myonecrosis edema Bothrops moojeni snake venom-injected gastrocnemius. Wistar rats receiving intramuscular venom injection (VBm) were compared with saline control (S) envenomed exposure plant (VExt) or (VL). phytochemistry thin-layer chromatography S. indicated presence phenolic compounds like gallic acid flavonoids including quercetin. Gastrocnemius VExt VL groups had a significant reduction creatine kinase (CK) activities greater Myogenin (MyoG) expression VBm group, efficacy better than exposure. Reduction serum CK reflects lessening muscle damage, whereas increase MyoG indicates myoblast differentiation acceleration repair. richness in flavonoids, such as light modulatory ability triggering multitude cell signalings likely underlie positive outcomes. Our findings suggest both treatments potential auxiliary tools be explored clinical trials combination anti-venom therapy after Bothropic snakebites.