Benefit: “Therapeutic Indication“

Current practices and future directions of therapeutic strategy in glioblastoma: survival benefit and indication of BNCT.

Since 1998, we are performing clinical studies on treatment of GBM using conventional fractionated photon radiation therapy (CRT), proton beam therapy (PBT) or boron neutron capture therapy (BNCT). We investigated whether these radiation modalities improves the survival of patients with GBM. Sixty-eight cases of newly diagnosed GBM have been treated in our institution. After surgery, radiation ...

Local anesthetics and the inflammatory response: a new therapeutic indication?

LOCAL anesthetics (LA) are known for their ability to block Na channels. However, they have significant effects in several settings other than local and regional anesthesia or antiarrhythmic treatment, the areas in which they are used traditionally. These effects result from LAs interacting with other cellular systems as well. Interestingly, some of these effects occur at concentrations much lo...

Differentiating haemostasis from thrombosis for therapeutic benefit.

The central role of platelets in the formation of the primary haemostatic plug as well as in the development of arterial thrombosis is well defined. In general, the molecular events underpinning these processes are broadly similar. Whilst it has long been known that disturbances in blood flow, changes in platelet reactivity and enhanced coagulation reactions facilitate pathological thrombus for...

A new therapeutic indication of botulinum toxins: sialorrhea.

Therapeutic angiogenesis: new indication for endothelial NO synthase gene transfer.

Evidence continues to accumulate on the importance of NO in angiogenesis.1–7 A number of angiogenic substances, including vascular endothelial growth factor (VEGF), stimulate production of NO in endothelial cells.8,9 In vivo biosynthesis of NO is essential for angiogenesis induced by tissue ischemia.3 Angiogenesis is severely impaired in ischemic hindlimb of endothelial NO synthase (eNOS)defici...