Behavioral toxicology, risk assessment, and chlorinated hydrocarbons.

Behavioral toxicology, risk assessment, and chlorinated hydrocarbons.

Behavioral end points are being used with greater frequency in neurotoxicology to detect and characterize the adverse effects of chemicals on the nervous system. Behavioral measures are particularly important for neurotoxicity risk assessment since many known neurotoxicants do not result in neuropathology. The chlorinated hydrocarbon class consists of a wide variety of chemicals including polyc...

Assessment of biological effects of chlorinated hydrocarbons in osprey chicks.

Osprey (Pandion haliaetus) eggs were collected during 1995 and 1996 at seven sites along the Fraser and Columbia River systems of British Columbia, Canada, and Washington and Oregon, USA. Fifty-four eggs were placed into a laboratory incubator. Thirty-eight of the hatched chicks were sacrificed within 24 h. Hatching success did not differ among sites and therefore between treatment and referenc...

Toxicology and Risk Assessment of Pharmaceuticals

1 Introduction For many years, the main focus of environmental pollution has been on chemical and pharmaceutical manufacturers. Spectacular accidents, such as that at the BASF facility in amongst others, provided the impetus for improved safety and spillage regulations as well as driving the efforts for environmental modeling and improved analysis of environmental samples. More recently, attent...

Behavioral toxicology.

The new fields of behavioral toxicology and behavioral teratology investigate the outcome of specific toxic exposures in humans and animals on learning, memory, and behavioral characteristics. Three important classes of behavioral neurotoxicants are metals, solvents, and pesticides. The clearest data on the deleterious effects of prenatal exposure to toxicants comes from the study of two metals...

Neuropsychological assessment in behavioral toxicology--developing techniques and interpretative issues.