Behavior of Stem Cell Spermatogonia in the Adult Rat Irradiated Testis
نویسندگان
چکیده
منابع مشابه
Glycan stem-cell markers are specifically expressed by spermatogonia in the adult non-human primate testis.
BACKGROUND The glycan cell surface molecules, stage-specific embryonic antigen (SSEA)-1, -3 and -4 and tumor-rejection antigen (TRA)-1-60 and -1-81, are expressed in specific combinations by undifferentiated pluripotent cells, i.e. embryonic stem cells, induced pluripotent stem cells, embryonal carcinoma cells, primordial germ cells and embryonic germ cells. Upon differentiation of the cells, t...
متن کاملParacrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis.
Spermatogonial stem cells (SSCs) fuel the production of male germ cells but the mechanisms behind SSC self-renewal, proliferation, and differentiation are still poorly understood. Using the Wnt target gene Axin2 and genetic lineage-tracing experiments, we found that undifferentiated spermatogonia, comprising SSCs and transit amplifying progenitor cells, respond to Wnt/β-catenin signals. Genetic...
متن کامل'Side Population' cells in adult mouse testis express Bcrp1 gene and are enriched in spermatogonia and germinal stem cells.
Stem cells in various somatic tissues (bone marrow, skeletal muscle) can be identified by the 'Side Population' marker based on Hoechst 33342 efflux. We show that mouse testicular cells also display a 'Side Population' that express Bcrp1 mRNA, the ABC transporter responsible for Hoechst efflux in hematopoietic cells. Inhibition of Hoechst efflux by specific BCRP1 inhibitor Ko143 show that germi...
متن کاملEmbryonic stem cell-like cells derived from adult human testis.
BACKGROUND Given the significant drawbacks of using human embryonic stem (hES) cells for regenerative medicine, the search for alternative sources of multipotent cells is ongoing. Studies in mice have shown that multipotent ES-like cells can be derived from neonatal and adult testis. Here we report the derivation of ES-like cells from adult human testis. METHODS Testis material was donated fo...
متن کاملDeveloping and Adult Rat Testis
23 Iron is essential for male fertility and disruptions in iron balance lead to impairment of testicular 24 function. The divalent metal transporter DMT1 is a key modulator of transferrin and non-transferrin 25 bound iron homeostasis. As a first step in determining the role of DMT1 in the testis, we have 26 determined the pattern of DMT1 expression in the developing and adult rat testis. Northe...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 1978
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod19.4.747