BECLIN 1 - Регулаторен протеин на автофагията

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2, interacts with the evolutionarily conserved autophagy protein, Beclin 1. However, little is known about the functional significance of this interaction. Here, we show that wild-type Bcl-2 antiapoptotic proteins, but ...

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Regulation of the Autophagic Bcl-2/Beclin 1 Interaction

Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-XL and Mcl-1). This binding is regulated by a variety of proteins and compounds th...

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Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex

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ژورنال

عنوان ژورنال: Varna Medical Forum

سال: 2017

ISSN: 2367-5519,1314-8338

DOI: 10.14748/vmf.v6i2.4029