BECLIN 1 - Регулаторен протеин на автофагията
نویسندگان
چکیده
منابع مشابه
Beclin-1 Targeting for Viral Immune Escape
Macroautophagy is a catabolic pathway in eukaryotic cells that has recently been shown to facilitate pathogen detection, pathogen restriction and pathogen-derived antigen presentation to CD4(+) T cells. Due to these protective functions during immune responses, several pathogens, including RNA and DNA viruses, have developed strategies to inhibit autophagosome generation or maturation. Interest...
متن کاملRegulation of Beclin 1 in autophagy.
Class III phosphatidylinositol 3-kinase (PI3KC3) plays a pleiotropic role in autophagy and protein sorting pathways. The human core complex of PI3KC3 consists of three major components including PI3KC3/hVps34, p150 and Beclin 1. How the specificity of PI3KC3 complex is derived towards autophagy is not clear. Utilizing a sequential affinity purification coupled with mass spectrometry approach, w...
متن کاملBcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis, development, and disease. The anti-apoptotic protein, Bcl-2, interacts with the evolutionarily conserved autophagy protein, Beclin 1. However, little is known about the functional significance of this interaction. Here, we show that wild-type Bcl-2 antiapoptotic proteins, but ...
متن کاملRegulation of the Autophagic Bcl-2/Beclin 1 Interaction
Autophagy is an intracellular degradation process responsible for the delivery of cellular material to the lysosomes. One of the key mechanisms for control of autophagy is the modulation of the interaction between the autophagic protein Beclin 1 and the members of the anti-apoptotic Bcl-2 family (e.g., Bcl-2, Bcl-XL and Mcl-1). This binding is regulated by a variety of proteins and compounds th...
متن کاملCrystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressorBeclin 1has beenproposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and/or Bcl-XL. However, the molecular basis for this interaction remains enigmatic. Herewe report that Beclin 1 contains a conserved BH...
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ژورنال
عنوان ژورنال: Varna Medical Forum
سال: 2017
ISSN: 2367-5519,1314-8338
DOI: 10.14748/vmf.v6i2.4029