bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia.
نویسندگان
چکیده
منابع مشابه
bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia
Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.
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We report on a Ph+ chronic myelocytic leukemia (CML) case, cytogenetically characterized by the occurrence of a second Philadelphia (Ph) chromosome in lymphoid blast crisis of T cell lineage. In situ hybridization analyses showed a deletion of translocated c-abl sequences, present on the Ph during chronic state, from both Ph in acute state. Moreover, Southern blot analyses of blastic cells exhi...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1985
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.162.6.2175