منابع مشابه
Bayesian Protein Structure Alignment.
The analysis of the three-dimensional structure of proteins is an important topic in molecular biochemistry. Structure plays a critical role in defining the function of proteins and is more strongly conserved than amino acid sequence over evolutionary timescales. A key challenge is the identification and evaluation of structural similarity between proteins; such analysis can aid in understandin...
متن کاملProtein Structure Alignment Protein Structure Alignment
If we know the structures of the proteins A and B, and the function of protein A, then if we can detect structural similarity between A and B by producing an alignment between them, it can help us infer functionality of B. The problem of protein structure alignment is essentially similar to the sequence alignment; the fact that we have to do structural alignment in 3-d adds to the complexity of...
متن کاملFast Protein Structure Alignment
We address the problem of aligning the 3D structures of two proteins. Our pairwise comparisons are based on a new optimization model that is succinctly expressed in terms of linear transformations and highlights the problem’s intrinsic geometry. The optimization problem is approximately solved with a new polynomial time algorithm. The worstcase analysis of the algorithm shows that the solution ...
متن کاملBayesian Protein Structure Prediction
An important role for statisticians in the age of the Human Genome Project has developed in the emerging area of “structural bioinformatics”. Sequence analysis and structure prediction for biopolymers is a crucial step on the path to turning newly sequenced genomic data into biologically and pharmaceutically relevant information in support of molecular medicine. We describe our work on Bayesian...
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2014
ISSN: 1932-6157
DOI: 10.1214/14-aoas780