Basis of quinolone antibiotics
نویسندگان
چکیده
منابع مشابه
Ciprofloxacin use and susceptibility of Gram-negative organisms to quinolone and non-quinolone antibiotics.
OBJECTIVES A Trust strategy to reduce ciprofloxacin use was implemented at a University hospital. This study aimed to investigate whether the susceptibility of Gram-negative organisms (GNO) to alternative antimicrobials (co-amoxiclav, doxycycline, aztreonam, piperacillin/tazobactam, meropenem and gentamicin) changed, and whether there was any relationship between GNO susceptibility to these ant...
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Optically pure conjugates of quinolone antibiotics with naturally occurring amino acids are synthesized in 40-98% yields.
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Quinolones are clinically important antibiotic drugs. One quinolone antibiotic, sparfloxacin (SPX), has been recently reported to increase the QT interval, and another quinolone, grepafloxacin (GRX), was withdrawn because it induced torsade de pointes (TdP), a polymorphic ventricular tachycardia (VT) linked to excessive QT interval prolongation. To determine whether SPX, GRX, and other recently...
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Quinolones are synthetic broad-spectrum antibiotics with good oral absorption and excellent bioavailability. Due to the chemical functions found on their nucleus (a carboxylic acid function at the 3-position, and in most cases a basic piperazinyl ring (or another N-heterocycle) at the 7-position, and a carbonyl oxygen atom at the 4-position) quinolones bind metal ions forming complexes in which...
متن کاملCarrier-mediated hepatic uptake of quinolone antibiotics in the rat.
The systemic clearance of many quinolone antibiotics is mainly via metabolism and urinary excretion; by contrast, biliary excretion is a major route of elimination for a new quinolone grepafloxacin (GPFX). Accordingly, we studied the hepatic uptake of GPFX because it is the first step in the drug's hepatobiliary transport. The hepatic uptake of GPFX in vivo after i.v. administration was found t...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2007
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.130.287