Basal ganglia vulnerability to oxidative stress

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Basal ganglia vulnerability to oxidative stress

Increased levels of oxidative stress (OS) in the brain have been linked to the etiology of several neurodegenerative diseases, e.g., Alzheimer’s and Parkinson’s disease (Navarro and Boveris, 2009; Melo et al., 2011; Radak et al., 2011; Sultana et al., 2013). A possible cause of increased OS levels is an imbalance in the omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) (Kiecol...

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Oxidative stress (OS), caused by the imbalance between the generation and detoxification of reactive oxygen and nitrogen species (ROS/RNS), plays an important role in brain aging, neurodegenerative diseases, and other related adverse conditions, such as ischemia. While ROS/RNS serve as signaling molecules at physiological levels, an excessive amount of these molecules leads to oxidative modific...

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ژورنال

عنوان ژورنال: Frontiers in Neuroscience

سال: 2014

ISSN: 1662-453X

DOI: 10.3389/fnins.2014.00080