Barbiturate Interaction with Phosphatidylcholine

Barbiturate interaction with phosphatidylcholine.

A hydrogen-bonding interaction between phenobarbital or pentobarbital with phosphatidylcholine in chloroform is indicated by the effects of added phosphatidylcholine on the infrared and proton magnetic resonance spectra of these barbiturates. The nitrogenbound proton of the barbiturate and the orthophosphate moiety of the phosphatidylcholine molecule appear to be involved. The more pronounced e...

The interaction of apolipoprotein-serine with phosphatidylcholine.

Apolipoprotein-serine (apoLP-Ser) is one of the protein constituents of human plasma very low density lipoproteins (VLDL). The protein has 57 amino acids with 1 residue each of methionine and tryptophan. Cleavage of apoLP-Ser with cyanogen bromide yields the NHp-terminal fragment (CNBr I) and COOH-terminal fragment (CNBr II) having 38 and 19 residues, respectively. CNBr II contains the single r...

Interaction of Phenol-Soluble Modulins with Phosphatidylcholine Vesicles

Several members of the staphylococcal phenol-soluble modulin (PSM) peptide family exhibit pronounced capacities to lyse eukaryotic cells, such as neutrophils, monocytes, and erythrocytes. This is commonly assumed to be due to the amphipathic, α-helical structure of PSMs, giving PSMs detergent-like characteristics and allowing for a relatively non-specific destruction of biological membranes. Ho...

Mechanism of interaction of monovalent ions with phosphatidylcholine lipid membranes.

Interactions of different anions with phospholipid membranes in aqueous salt solutions were investigated by molecular dynamics simulations and fluorescence solvent relaxation measurements. Both approaches indicate that the anion-membrane interaction increases with the size and softness of the anion. Calculations show that iodide exhibits a genuine affinity for the membrane, which is due to its ...

Barbiturate Poisoning Treated with Picrotoxin