“Balancing” balancing selection? Assortative mating at the major histocompatibility complex despite molecular signatures of balancing selection
نویسندگان
چکیده
منابع مشابه
Polymorphism and balancing selection at major histocompatibility complex loci.
Amino acid replacements in the peptide-binding region (PBR) of the functional major histocompatibility complex (Mhc) genes appear to be driven by balancing selection. Of the various types of balancing selection, we have examined a model equivalent to overdominance that confers heterozygote advantage. As discussed by A. Robertson, overdominance selection tends to maintain alleles that have more ...
متن کاملBalancing claims for balancing selection.
Natural selection is expected to leave distinctive signatures on patterns of neutral variation that are tightly linked to a site carrying an advantageous mutation. This notion is the basis for molecular population genetics approaches to the analysis of adaptations in the human genome. In principle, this is an attractive prospect; in practice, several complications and challenges make it difficu...
متن کاملBalancing selection
sophisticated culture of the native North Carolina Algonquian Indians he encountered. In 1585, John White returned from ‘Virginia’ with visions of the perfect place to plant the English in the New World. While Raleigh continued preparations for a permanent colony of 115 men, women and children at Chesapeake, John White was appointed governor. But the project failed for lack of supplies and reli...
متن کاملI-14: Ethical Issues in Sex Selection and Family Balancing
Sex selection for non-medical reasons is a major controversy in around the world. Here in this paper, we presented the ethical arguments about sex selection for non-medical reasons and discuss about them in Islamic context. Significant arguments about sex selection relate to sexism and sex discrimination, sex disproportion, human dignity, playing God, psychological pressure on unselected childr...
متن کاملEvidence for balancing selection at HLA.
HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Ecology and Evolution
سال: 2019
ISSN: 2045-7758,2045-7758
DOI: 10.1002/ece3.5087