Balance between Estrogens and Proinflammatory Cytokines Regulates Chemokine Production Involved in Thymic Germinal Center Formation

LKB1 regulates germinal center formation and termination.

LKB1 regulates germinal center formation and termination Lynnea R Waters, Nicole C Walsh & Michael A Teitell a Molecular Biology Institute; University of California at Los Angeles; Los Angeles, CA USA b Department of Pathology and Laboratory Medicine; University of California at Los Angeles; Los Angeles, CA USA c Broad Stem Cell Research Center; Department of Pediatrics and Bioengineering; Cali...

Thymoma and thymic germinal center.

A previous study of 70 cases of thymoma described in 1966 by the author1 reported that definite germinal centers were found in the normal thymic tissue attached to one case of thymoma associated with myasthenia gravis, and that this was very interesting from the point of view of whether thymoma or thymic germinal center was a more important occurrence of a myasthenic condition. Since then routi...

Cytokines in the Germinal Center Niche

Cytokines are small, secreted, glycoproteins that specifically affect the interactions and communications between cells. Cytokines are produced transiently and locally, acting in a paracrine or autocrine manner, and they are extremely potent, ligating high affinity cell surface receptors to elicit changes in gene expression and protein synthesis in the responding cell. Cytokines produced during...

Chemokine Ligand (CXCL)12 and CXCL13 Lymphocytes Responsiveness to CXC RGS13 Regulates Germinal Center B

ANG II is involved in the LPS-induced production of proinflammatory cytokines in dehydrated rats.

We have previously reported results that led us to speculate that ANG II is involved in the LPS-induced production of proinflammatory cytokines, especially under dehydrated conditions. To test this possibility, in this study we examined the effects of an angiotensin-converting enzyme (ACE) inhibitor and an antagonist of the type-1 ANG II receptor (AT(1) receptor) on the LPS-induced production o...