Balance beam crossing times are slower after noise exposure in rats

Introduction The vestibular system integrates signals related to vision, head position, gravity, motion, and body position provide stability during motion through the environment. Disruption in any of these systems can reduce agility lead changes ability safely navigate one’s Causes decline are diverse; however, excessive noise exposure otolith organ dysfunction. Specifically, 120 decibel (dB) sound pressure level (SPL) 1.5 kHz-centered 3-octave band (1.5 kHz 3OBN) causes peripheral dysfunction rats, measured by short-latency evoked potential (VsEP) reduced calretinin-immunolabeling calyx-only afferent terminals striolar region saccule. present study examined functional impact this condition, examining motor performance after with a balance beam crossing task. Methods Balance time rats was assessed for 19 weeks before 5 exposure. crossings were scored assess proficiency When animals proficient, they received single dB SPL noise. Results During initial training phase slower times higher scores, including multiple failures observed. This followed period significant improvement leading proficiency, characterized fast stable consistently low scores. After exposure, significantly elevated from baseline 4-weeks. A total improved, though still trending than baseline, no longer different baseline. Discussion These findings show that noise-induced we previously observed at cellular electro-physiological levels also have an level. It has been shown imbalance is associated walking speed older adults aged rats. noise-exposed may implications people who experience noisy environments seniors history disorders be increased fall risk.