Bacteroides, butyric acid and t10,c12-CLA changes in colorectal adenomatous polyp patients

Abstract Background Colorectal adenomatous polyps (CAPs) are considered precancerous lesions of colorectal cancer (CRC). The gut microbiota participates in the process digestion and, process, produces metabolites, mainly short-chain fatty acids (SCFAs), secondary bile and conjugated linoleic acid (CLA). This study aimed to investigate constituents metabolites faeces CAP patients identify or that can be used as sensitive biological predictors provide a theoretical basis for clinical treatment CAPs. Methods 16S rRNA sequence analysis was detect microbial changes patients. qPCR evaluate ability produce contents were detected by ion chromatography ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Results Based on detection microbiota, with CAPs had increased abundances Bacteroides Citrobacter , Weissella Lactobacillus decreased. We also explored gene expression, abundance butyrate-producing bacterial genes significantly patients, but those acid-producing CLA-producing showed no differences faecal samples. acetic butyric group, healthy control group higher t10,c12-CLA . Conclusion results, assessed faeces, positively correlated CAPs, which indicated specific genera might detrimental intestinal health. In addition, played an important role protecting intestine.