منابع مشابه
Bacterial pyrogenic exotoxins as superantigens.
The recent discovery of the mode of interaction between a group of microbial proteins known as superantigens and the immune system has opened a wide area of investigation into the possible role of these molecules in human diseases. Superantigens produced by certain viruses and bacteria, including Mycoplasma species, are either secreted or membrane-bound proteins. A unique feature of these prote...
متن کاملShocking superantigens promote establishment of bacterial infection.
Streptococcus pyogenes, also referred to as group A Streptococcus (GAS), is an exclusive human pathogen causing diseases ranging from uncomplicated infections of the throat and skin to severe invasive infections, such as necrotizing fasciitis and streptococcal toxic shock syndrome (STSS). Asymptomatic carriage, particularly in the nasoand oropharyngeal mucosa, is common. GAS is equipped with an...
متن کاملSuperantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization
Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system activation. Staphylococcus aureus possesses a large repertoire of distinct SAgs, and in the context of host-pathogen interactions, staphylococcal SAg research has focused primarily on the role of these toxins in s...
متن کاملRecombinant Staphylococcus aureus exfoliative toxins are not bacterial superantigens.
Staphylococcal scalded-skin syndrome is an exfoliative dermatitis characterized by the separation of the epidermis at the stratum granulosum. This disruption is mediated by one of two Staphylococcus aureus exotoxins, exfoliative toxins A and B (ETA and ETB). Both ETA and ETB have been reported to be bacterial superantigens. A controversy exists, however, as other data indicate that these exotox...
متن کاملInhibition of bacterial superantigens by peptides and antibodies.
The pyrogenic exotoxins of group A streptococci and staphylococcal enterotoxins are a family of structurally related superantigens with similar biological activity. Two distinct areas have been identified which have a highly conserved amino acid homology in all of the toxin families. A number of peptides were constructed from these regions, some of which were concatenated and polymerized to enh...
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ژورنال
عنوان ژورنال: Clinical & Experimental Immunology
سال: 2003
ISSN: 0009-9104
DOI: 10.1046/j.1365-2249.2003.02203.x