Bacterial pathogenesis: Fis: global but specific
نویسندگان
چکیده
منابع مشابه
Bacterial Pathogenesis
Numerous physical and chemical attributes of the host protect against bacterial infection. These defenses include the antibacterial factors in secretions covering mucosal surfaces and rapid rate of replacement of skin and mucosal epithelial cells. Once the surface of the body is penetrated, bacteria encounter an environment virtually devoid of free iron needed for growth, which requires many of...
متن کاملGenomics and bacterial pathogenesis.
Whole-genome sequencing is transforming the study of pathogenic bacteria. Searches for single virulence genes can now be performed on a genomewide scale by a variety of computer and genetic techniques. These techniques are discussed to provide a perspective on the developing field of genomics.
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A pathogen is a microorganism that is able to cause disease in a plant, animal or insect. Pathogenicity is the ability to produce disease in a host organism. Microbes express their pathogenicity by means of their virulence, a term which refers to the degree of pathogenicity of the microbe. Hence the determinants of virulence of a pathogen are any of its genetic or biochemical or structural feat...
متن کاملPathogenesis of Bacterial Infection
All humans are infected with bacteria (the normal flora) living on their external surfaces (including the skin, gut and lungs). We are constantly also exposed to bacteria (including air, water, soil and food). Normally due to our host defenses most of these bacteria are harmless. In compromised patients, whose defenses are weakened, these bacteria often cause opportunistic infectious diseases w...
متن کاملDissecting specific and global transcriptional regulation of bacterial gene expression
Gene expression is regulated by specific transcriptional circuits but also by the global expression machinery as a function of growth. Simultaneous specific and global regulation thus constitutes an additional--but often neglected--layer of complexity in gene expression. Here, we develop an experimental-computational approach to dissect specific and global regulation in the bacterium Escherichi...
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ژورنال
عنوان ژورنال: Nature Reviews Microbiology
سال: 2004
ISSN: 1740-1526,1740-1534
DOI: 10.1038/nrmicro969