Bacterial Origin of a Mitochondrial Outer Membrane Protein Translocase
نویسندگان
چکیده
منابع مشابه
Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin
Mitochondria are found in all eukaryotic cells and derive from a bacterial endosymbiont [1, 2]. The evolution of a protein import system was a prerequisite for the conversion of the endosymbiont into a true organelle. Tom40, the essential component of the protein translocase of the outer membrane, is conserved in mitochondria of almost all eukaryotes but lacks bacterial orthologs [3-6]. It serv...
متن کاملThe preprotein translocase of the mitochondrial outer membrane.
The translocase components of the mitochondrial outer membrane (Tom) are essential for the transfer of preproteins from the cytosol to the mitochondria. At least nine Tom components have now been identified and they fall into two categories; receptor components and components of the General Import Pore (GIP). The receptor components most likely diffuse laterally in the membrane and deposit prep...
متن کاملThe Outer Mitochondrial Membrane Protein mitoNEET
Received for publication, May 31, 2007, and in revised form, June 20, 2007 Published, JBC Papers in Press, June 21, 2007, DOI 10.1074/jbc.C700107200 Sandra E. Wiley, Mark L. Paddock, Edward C. Abresch, Larry Gross, Peter van der Geer , Rachel Nechushtai**, Anne N. Murphy, Patricia A. Jennings, and Jack E. Dixon From the Departments of Pharmacology, Physics, Chemistry and Biochemistry, and Cellu...
متن کاملTbLOK1/ATOM19 is a novel subunit of the noncanonical mitochondrial outer membrane protein translocase of Trypanosoma brucei.
TbLOK1 has previously been characterized as a trypanosomatid-specific mitochondrial outer membrane protein whose ablation caused a collapse of the mitochondrial network, disruption of the membrane potential and loss of mitochondrial DNA. Here we show that ablation of TbLOK1 primarily abolishes mitochondrial protein import, both in vivo and in vitro. Co-immunprecipitations together with blue nat...
متن کاملA First Glimpse at the Structure of the Tom Translocase from the Mitochondrial Outer Membrane
T HREE DIMENSIONAL (3D) 1 image reconstruction from electron micrographs is providing a wealth of new structural information on complexes formerly intractable to solution. Nowhere will this technique be more important than in the analysis of multisubunit membraneembedded complexes, where the nature of the membrane interactions makes crystallization of the intact complex exceedingly difficult. T...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.m112.392118