Back Cover: Prodrug Activation by Gold Artificial Metalloenzyme‐Catalyzed Synthesis of Phenanthridinium Derivatives via Hydroamination (Angew. Chem. Int. Ed. 22/2021)
نویسندگان
چکیده
A gold artificial metalloenzyme (ArM) is reported by Katsunori Tanaka and co-workers in their Research Article on page 12446 to catalyze the synthesis of a phenanthridinium-based anticancer drug via hydroamination. This gold-based ArM shows excellent bioorthogonal activity, as hydroamination reaction proceeds with high turnover under physiological conditions. The vivo synthesized exerted therapeutic effect, highlighting potential usefulness synthetic chemistry.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/anie.202105326