B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation
نویسندگان
چکیده
منابع مشابه
Analysis of B Cell Repertoire Dynamics Following Hepatitis B Vaccination in Humans, and Enrichment of Vaccine-specific Antibody Sequences.
Generating a diverse B cell immunoglobulin repertoire is essential for protection against infection. The repertoire in humans can now be comprehensively measured by high-throughput sequencing. Using hepatitis B vaccination as a model, we determined how the total immunoglobulin sequence repertoire changes following antigen exposure in humans, and compared this to sequences from vaccine-specific ...
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BACKGROUND Improvements to the outcome of adaptive immune responses could be achieved by inducing specific natural killer (NK) cell subsets which can cooperate with dendritic cells to select efficient T cell responses. We previously reported the induction or reactivation of T cell responses in chronic hepatitis B patients vaccinated with a DNA encoding hepatitis B envelope proteins during a pha...
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© 2008 Weller et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 6 1331-1342 www.jem.org/cgi/doi/10.1084/jem.20071555 1331 In humans, peripheral blood B cells expressing the CD27 marker and mutated Ig receptors are usually considered to be memory B cells generated in germinal centers (GCs) during immune responses to T-dependent (TD) antigens. In adults, approximately half ...
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Aging is associated with hyporesponse to vaccination, whose mechanisms remain unclear. In this study hepatitis B virus (HBV)-naive older adults received three vaccines, including one against HBV. Here we show, using transcriptional and cytometric profiling of whole blood collected before vaccination, that heightened expression of genes that augment B-cell responses and higher memory B-cell freq...
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ژورنال
عنوان ژورنال: Genome Medicine
سال: 2016
ISSN: 1756-994X
DOI: 10.1186/s13073-016-0322-z