B-cell monoclonal lymphocytosis and B-cell abnormalities in the setting of familial B-cell chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Monoclonal B-Cell Lymphocytosis
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic hematologic condition defined by the presence of a small (<5 x 10(9)/L) clonal B-cell population in the peripheral blood in the absence of lymph-node enlargement, cytopenias or autoimmune diseases. It is found in approximately 3-12% of normal persons depending on the accuracy of analytical techniques applied. According to the immunophenot...
متن کاملMonoclonal B-cell lymphocytosis☆
Chronic B-cell lymphocytic leukemia (B-CLL) represents 0.9% of all new cancers. It is estimated that there will be almost 15 000 new cases and 4600 deaths due to CLL in 2015 in the USA.1 The median ages at diagnosis and death are 71 years and 80 years, respectively.1 The criteria that define the diagnosis of B-CLL include the presence of at least 5 × 106 B lymphocytes/L with the peculiar CLL ph...
متن کاملMonoclonal B-cell lymphocytosis.
The incidence and presenting features of chronic lymphocytic leukemia (CLL) have changed significantly over the last century. Routine diagnostic techniques can now detect very low levels of CLL phenotype cells. Monoclonal B-cell lymphocytosis (MBL) is a relatively recent diagnostic category encapsulating individuals with an abnormal B-cell population but not meeting the diagnostic criteria for ...
متن کاملB-cell Chronic Lymphocytic Leukemia
Purpose: To review the recent major advances in the molecular and cell biology of B-cell chronic lymphocytic leukemia (B-CLL). Methods: Weanalyzed thenatureofmalignantB-CLLB cells and their interactions with the microenvironment. Results: B-CLL is a malignancy of a mantle zonebased subpopulation of anergic, self-reactive, activated CD51 B cells devoted to the production of polyreactive natural ...
متن کاملFrequency of monoclonal B-cell lymphocytosis in relatives of patients with chronic lymphocytic leukemia
INTRODUCTION Monoclonal B-cell lymphocytosis is a symptom free condition characterized by the circulation of small clonal population of B lymphocytes in peripheral blood (less than 5x10(9)/L) expressing an immunophenotype similar to chronic lymphocytic leukemia. Different studies based on big hospital series have manifested a higher risk in subjects with monoclonal B-cell lymphocytosis to progr...
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ژورنال
عنوان ژورنال: Cytometry
سال: 2003
ISSN: 0196-4763,1097-0320
DOI: 10.1002/cyto.b.10013