Azelnidipine Down-Regulates Renal Angiotensin-Converting Enzyme and Mineralocorticoid Receptor mRNA in Diabetic Hypertensive Rats

Renal GLUT1 reduction depends on angiotensin-converting enzyme inhibition in diabetic hypertensive rats.

AIMS Angiotensin-converting enzyme (ACE) inhibitors are used in diabetic kidney disease to reduce systemic/intra-glomerular pressure. The objective of this study was to investigate whether reducing blood pressure (BP) could modulate renal glucose transporter expression, and urinary markers of diabetic nephropathy in diabetic hypertensive rats treated with ramipril or amlodipine. MAIN METHODS ...

Reduced cortical renal GLUT1 expression induced by angiotensin-converting enzyme inhibition in diabetic spontaneously hypertensive rats.

Diabetes in spontaneously hypertensive rats is associated with cortical renal GLUT1 and GLUT2 overexpression. Our objective was to evaluate the effect of the angiotensin-converting enzyme blockade on cortical renal GLUT1 and GLUT2 expression, urinary albumin and urinary TGF-beta1. Streptozotocin, 50 mg/kg, or citrate buffer (N = 16) was administered as a single injection into the tail vein in a...

Angiotensin Converting Enzyme in Sarcoidosis

Angiotensin converting enzyme variability in hypertensive and normotensive rats.

Recent data have revealed biological and genetic variability in normotensive Wistar-Kyoto rats, which are considered to be the most appropriate control strain for spontaneously hypertensive rats. To investigate the possibility that angiotensin converting enzyme activity could be affected by this variability, we measured plasma and tissue (lung, heart, renal cortex, renal medulla, and adrenal gl...

Hypertensive rebound after angiotensin converting enzyme inhibitor withdrawal in diabetic patients with chronic renal failure.

Sir, Although angiotensin-converting enzyme (ACE) inhibitors are considered a milestone in the treatment of hypertension and microalbuminuria in diabetic patients w1,2x, some cau-tionary notes were reported in the setting of signi®cant reduction of renal function w3±5x. Discrepancy between long-term trials w1,2x and anecdotal reports w3±5x is probably due to the different selection of patients ...