Azaphilones Inhibit Tau Aggregation and Dissolve Tau Aggregatesin Vitro
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چکیده
منابع مشابه
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells.
The abnormal aggregation of tau protein into paired helical filaments (PHFs) is one of the hallmarks of Alzheimer's disease. Aggregation takes place in the cytoplasm and could therefore be cytotoxic for neurons. To find inhibitors of PHF aggregation we screened a library of 200,000 compounds. The hits found in the PHF inhibition assay were also tested for their ability to dissolve preformed PHF...
متن کاملAnthraquinones inhibit tau aggregation and dissolve Alzheimer paired helical filaments in vitro and in cells
The abnormal aggregation of tau protein into paired helical filaments (PHFs) is one of the hallmarks of Alzheimer’s disease. Aggregation takes place in the cytoplasm and could therefore be cytotoxic for neurons. In order to find inhibitors of PHF aggregation we screened a library of 200.000 compounds. The hits found in the PHF inhibition assay were JBC Papers in Press. Published on November 2, ...
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Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly. The inhibitors can be clustered in several compound c...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2015
ISSN: 1948-7193,1948-7193
DOI: 10.1021/acschemneuro.5b00013