منابع مشابه
Migraine meets membrane trafficking.
Having a drug that works clinically, but without a clear mechanism, is like having a key that can be tried on many doors—eventually one will open, but what will be found? The paper by Burstein and colleagues (1) in this issue of Cephalalgia describes an unexpected connection between migraine and membrane trafficking associated with mechanical pain. In an elegant series of experiments, they show...
متن کاملUbiquitin meets PIWI protein.
M IWI and PIWI-interacting RNA (piRNA), which binds to PIWI family members including MIWI, contribute to post-transcriptional regulation in spermiogenesis, however, their molecular functions had been unclear. Recently, Zhao and colleagues reported that loading of piRNA to MIWI leads to ubiquitin-proteasome mediated degradation in late spermatid and that this process is essential for the maturat...
متن کاملRegulators of kinesin involved in polarized trafficking and axon outgrowth
Proteins such as UNC-76 that associate with kinesin motors are important in directing neurite extension. A small Caenorhabditis elegans coiled-coil protein, UNC-69, has now been shown to interact with UNC-76 and to be involved in axonal (but not dendritic) transport and outgrowth, as well as synapse formation.
متن کاملMembrane Trafficking: An Endosome Tether Meets a Rab and Collapses
Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating short-range interactions required for fusion.
متن کاملThe neurotrophin receptor signaling endosome: Where trafficking meets signaling.
Neurons are the largest cells in the body and form subcellular compartments such as axons and dendrites. During both development and adulthood building blocks must be continually trafficked long distances to maintain the different regions of the neuron. Beyond building blocks, signaling complexes are also transported, allowing for example, axons to communicate with the soma. The critical roles ...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2002
ISSN: 1534-5807
DOI: 10.1016/s1534-5807(02)00260-5