Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1
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چکیده
منابع مشابه
Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.
Axin promotes the phosphorylation of beta-catenin by GSK-3beta, leading to beta-catenin degradation. Wnt signals interfere with beta-catenin turnover, resulting in enhanced transcription of target genes through the increased formation of beta-catenin complexes containing TCF transcription factors. Little is known about how GSK-3beta-mediated beta-catenin turnover is regulated in response to Wnt...
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ishevelled (DVL) is associated with axonal microtubules and regulates microtubule stability through the inhibition of the serine/threonine kinase, glycogen synthase kinase 3 (GSK-3 ). In the canonical WNT pathway, the negative regulator Axin forms a complex with -catenin and GSK-3 , resulting in -catenin degradation. Inhibition of GSK-3 by DVL increases -catenin stability and TCF transcriptiona...
متن کاملA divergent canonical WNT-signaling pathway regulates microtubule dynamics
Dishevelled (DVL) is associated with axonal microtubules and regulates microtubule stability through the inhibition of the serine/threonine kinase, glycogen synthase kinase 3beta (GSK-3beta). In the canonical WNT pathway, the negative regulator Axin forms a complex with beta-catenin and GSK-3beta, resulting in beta-catenin degradation. Inhibition of GSK-3beta by DVL increases beta-catenin stabi...
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Aschenbach, William G., Richard C. Ho, Kei Sakamoto, Nobuharu Fujii, Yangfeng Li, Young-Bum Kim, Michael F. Hirshman, and Laurie J. Goodyear. Regulation of Dishevelled and -catenin in rat skeletal muscle: an alternative exercise-induced GSK-3 signaling pathway. Am J Physiol Endocrinol Metab 291: E152–E158, 2006. First published February 14, 2006; doi:10.1152/ajpendo.00180.2005.— catenin is a mu...
متن کاملInhibition of the Wnt signaling pathway by the PR61 subunit of protein phosphatase 2A.
Axin, a negative regulator of the Wnt signaling pathway, forms a complex with glycogen synthase kinase-3beta (GSK-3beta), beta-catenin, adenomatous polyposis coli (APC) gene product, and Dvl, and it regulates GSK-3beta-dependent phosphorylation in the complex and the stability of beta-catenin. Using yeast two-hybrid screening, we found that regulatory subunits of protein phosphatase 2A, PR61bet...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1999
ISSN: 1460-2075
DOI: 10.1093/emboj/18.15.4233