Avoiding False Positives in Colony PCR

Virtual elimination of false positives in blue-white colony screening.

False positives in cancer epidemiology.

BACKGROUND A recent attempt to estimate the false-positive rate for cancer epidemiology studies is based on agents in International Agency for Research on Cancer (IARC) category 3 (agent not classifiable as to its carcinogenicity to humans) in the IARC Monographs Program. METHODS The estimation method is critiqued regarding biases caused by its reliance on the IARC classification criteria for...

The difficulty of avoiding false positives in genome scans for natural selection.

Several studies have found evidence for more positive selection on the chimpanzee lineage compared with the human lineage since the two species split. A potential concern, however, is that these findings may simply reflect artifacts of the data: inaccuracies in the underlying chimpanzee genome sequence, which is of lower quality than human. To test this hypothesis, we generated de novo genome a...

Minimizing false positives in differential display.

Avoiding false positives: zones of rarity, the threshold problem, and the DSM clinical significance criterion.

False positives arise when people without disorders are diagnosed as having disorders. Various approaches for avoiding false positives have been suggested. This review critically assesses the roles of zones of rarity, the threshold problem (the problem of determining the boundary of disorder in cases that shade into normality), and the Diagnostic and Statistical Manual of Mental Disorders (DSM)...