Au–ZnO Conjugated Black Phosphorus as a Near-Infrared Light-Triggering and Recurrence-Suppressing Nanoantibiotic Platform against Staphylococcus aureus

Antibiotic therapy is the gold standard for bacterial infections treatment. However, rapid increase in multidrug-resistant (MDR) and its recent use secondary many COVID-19 patients has considerably weakened treatment efficacy. These shortcomings motivated researchers to develop new antibacterial materials, such as nanoparticle-based platform with ability chances of killing MDR strains prevent their drug resistance. Herein, we report a black phosphorus (BP)-based non-damaging near-infrared light-responsive conjugated ZnO Au nanoparticles synergistic agent against Staphylococcus aureus species. First, BP nanosheets containing were assembled situ prepared by low-temperature solution synthesis method. Subsequently, activities resulting Au–ZnO–BP nanocomposite non-resistant, methicillin-resistant, erythromycin-resistant S. species determined, after photothermal efficacy was assessed. The synthesized exhibited excellent anti-S. activity good characteristics. non-resistant did not produce drug-resistant bacteria multiple consecutive passages under pressure proposed nanoantibiotic, but rapidly developed resistance erythromycin. This work clearly demonstrates properties